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(min-width:1024px){.container-main{padding-left:2rem;padding-right:2rem}}@media (min-width:1536px){.container-main{max-width:1400px}}.grid-12{grid-template-columns:repeat(12,minmax(0,1fr));gap:1.5rem;display:grid}@media (min-width:1024px){.grid-12{gap:2rem}}@media (min-width:1280px){.grid-12{gap:2.5rem}}@media (min-width:1536px){.grid-12{gap:3rem}}.content-sidebar{grid-template-columns:1fr;gap:1.5rem;display:grid}.content-sidebar>:first-child{min-width:0}@media (min-width:1024px){.content-sidebar{grid-template-columns:1fr 300px;gap:2rem}}@media (min-width:1280px){.content-sidebar{grid-template-columns:1fr 340px;gap:2.5rem}}@media (min-width:1536px){.content-sidebar{grid-template-columns:repeat(12,minmax(0,1fr));gap:3rem}.content-sidebar>:first-child{grid-column:span 8/span 8;min-width:0}.content-sidebar>:nth-child(2){grid-column:span 4/span 4}}.prose-column{max-width:100%}@media (min-width:1280px){.prose-column{max-width:72ch}}.prose-column .prose-break-out{width:100%;max-width:none}#article-body .prose{max-width:none}#article-body .prose>:not(figure){max-width:65ch}.section-spacing{padding-top:2rem;padding-bottom:2rem}@media (min-width:768px){.section-spacing{padding-top:2.5rem;padding-bottom:2.5rem}}@media (min-width:1024px){.section-spacing{padding-top:3rem;padding-bottom:3rem}}.section-header{align-items:center;gap:1rem;margin-bottom:1.5rem;display:flex}.section-header:after{content:"";background:var(--color-neutral-200);flex:1;height:1px}.section-header h2,.section-header h3{white-space:nowrap;margin:0}@keyframes shimmer{0%{background-position:-200% 0}to{background-position:200% 0}}.skeleton{background:linear-gradient(90deg,var(--color-neutral-200) 25%,var(--color-neutral-100) 50%,var(--color-neutral-200) 75%);border-radius:var(--radius-sm);background-size:200% 100%;animation:shimmer 1.5s infinite}@keyframes fade-in{0%{opacity:0}to{opacity:1}}@keyframes ticker-scroll{0%{transform:translate(0)}to{transform:translate(-50%)}}@keyframes pulse-dot{0%,to{opacity:1}50%{opacity:.4}}@keyframes ad-pulse{0%,to{box-shadow:0 0 #1f618d00}50%{box-shadow:0 0 0 3px #1f618d14}}.ad-highlight{animation:ad-pulse 3s ease-in-out infinite}@media (prefers-reduced-motion:reduce){.ad-highlight{animation:none}}.animate-fade-in{animation:fade-in .5s ease-out both}.animate-ticker{animation:ticker-scroll 60s linear infinite}.animate-ticker:hover{animation-play-state:paused}.card-hover{transition:border-color var(--transition-timing-fast)}.card-hover:hover{border-color:var(--color-brand-dark)}.card-image-zoom{overflow:hidden}.card-image-zoom img{will-change:transform;transition:transform .5s ease-out}.card-image-zoom:hover img{transform:scale(1.05)}.breaking-ticker{white-space:nowrap;background:var(--color-neutral-100);color:var(--color-neutral-600);font-family:var(--font-sans);font-size:.875rem;font-weight:500;overflow:hidden}.breaking-ticker--alert{color:#fff;background:#dc2626}.breaking-ticker__label{background:var(--color-neutral-700);color:var(--color-neutral-100);text-transform:uppercase;letter-spacing:.08em;z-index:2;flex-shrink:0;align-items:center;gap:.5rem;padding:.5rem 1rem;font-size:.75rem;font-weight:700;display:inline-flex;position:relative}.breaking-ticker__label:before{content:"";background:var(--color-neutral-300);border-radius:50%;width:6px;height:6px;animation:pulse-dot 1.5s ease-in-out infinite}.breaking-ticker--alert .breaking-ticker__label{color:#fff;background:#991b1b}.breaking-ticker--alert .breaking-ticker__label:before{background:#fff;animation:pulse-dot .8s ease-in-out infinite}.breaking-ticker__track{animation:ticker-scroll var(--ticker-duration,60s) linear infinite;display:inline-block}.breaking-ticker__track:hover{animation-play-state:paused}@media (max-width:768px){.breaking-ticker__track{animation-duration:calc(var(--ticker-duration,60s) * .6)}}.breaking-ticker__item{padding:0;display:inline-block}.breaking-ticker__item:after{content:"•";text-align:center;opacity:.35;width:5rem;display:inline-block}.breaking-ticker--alert .breaking-ticker__item:after{color:#fff;opacity:.5}.breaking-ticker--sponsored .breaking-ticker__label:before{opacity:.6;background:currentColor;animation-duration:2s}.breaking-ticker--sponsored .breaking-ticker__item:after{color:currentColor;opacity:.4}@media (max-width:768px){.breaking-ticker__item:after{width:2.5rem}}.eye-blink-top{animation:eye-blink 6s ease-in-out infinite;transform:translateY(-100%)}.eye-blink-bottom{animation:eye-blink-bottom 6s ease-in-out infinite;transform:translateY(100%)}@keyframes eye-blink{0%,90%,to{transform:translateY(-100%)}94%,96%{transform:translateY(0)}}@keyframes eye-blink-bottom{0%,90%,to{transform:translateY(100%)}94%,96%{transform:translateY(0)}}@keyframes bubble-emerge{0%{opacity:0;transform:scale(.15)translate(40px)}30%{opacity:1;transform:scale(.6)translate(16px)}60%{transform:scale(1.06)translate(-4px)}75%{transform:scale(.97)translate(2px)}90%{transform:scale(1.01)translate(-1px)}to{opacity:1;transform:scale(1)translate(0)}}@keyframes bubble-dismiss{0%{opacity:1;transform:scale(1)translate(0)}to{opacity:0;transform:scale(.2)translate(40px)}}.category-pill{font-family:var(--font-sans);text-transform:uppercase;letter-spacing:.06em;border-radius:var(--radius-pill);background-color:currentColor;align-items:center;gap:.375rem;padding:.3125rem .75rem;font-size:.6875rem;font-weight:700;line-height:1;display:inline-flex}@supports (color:color-mix(in lab,red,red)){.category-pill{background-color:color-mix(in srgb,currentColor 12%,transparent)}}.category-pill{transition:background-color var(--transition-timing-fast),color var(--transition-timing-fast)}.category-pill:hover{background-color:currentColor}@supports (color:color-mix(in lab,red,red)){.category-pill:hover{background-color:color-mix(in srgb,currentColor 20%,transparent)}}.category-pill:hover{text-decoration:none}.category-pill--features{color:var(--color-cat-features)}.category-pill--news{color:var(--color-cat-news)}.category-pill--comment{color:var(--color-cat-comment)}.category-pill--ophthalmology{color:var(--color-cat-ophthalmology)}.category-pill--research{color:var(--color-cat-research)}.category-pill--dispensing{color:var(--color-cat-dispensing)}.category-pill--business{color:var(--color-cat-business)}.category-pill--dry-eye{color:var(--color-cat-dry-eye)}.link-underline{text-decoration:none;position:relative}.link-underline:after{content:"";transform-origin:100%;width:100%;height:2px;transition:transform var(--transition-timing-slow);background-color:currentColor;position:absolute;bottom:-1px;left:0;transform:scaleX(0)}.link-underline:hover:after{transform-origin:0;transform:scaleX(1)}.link-underline-subtle{text-decoration:none;position:relative}.link-underline-subtle:after{content:"";opacity:.25;width:100%;height:1px;transition:opacity var(--transition-timing-fast),height var(--transition-timing-fast);background-color:currentColor;position:absolute;bottom:-1px;left:0}.link-underline-subtle:hover:after{opacity:.6;height:2px}.link-headline{color:inherit;transition:color var(--transition-timing-fast);text-decoration:none}.link-headline:hover{color:var(--color-neutral-600);text-decoration:none}.divider-accent{background:var(--color-neutral-200);border:none;height:1px;position:relative}.divider-accent:after{content:"";background:var(--color-brand-dark);border-radius:2px;width:3rem;height:3px;position:absolute;top:-1px;left:0}.divider-accent--center:after{left:50%;transform:translate(-50%)}.divider-accent--wide:after{width:5rem}.meta-text{font-family:var(--font-sans);color:var(--color-neutral-700);font-size:.8125rem;line-height:1.4}.meta-separator:before{content:"·";color:var(--color-neutral-400);margin:0 .375rem}.skip-to-content{z-index:9999;background:var(--color-brand-dark);width:1px;height:1px;color:var(--color-neutral-0);font-family:var(--font-sans);border-radius:0 0 var(--radius-sm) var(--radius-sm);padding:.75rem 1.5rem;font-size:.875rem;font-weight:600;text-decoration:none;position:absolute;top:auto;left:-9999px;overflow:hidden}.skip-to-content:focus{width:auto;height:auto;position:fixed;top:0;left:1rem;overflow:visible}.focus-ring:focus-visible,.skip-to-content:focus{outline:2px solid var(--color-brand-dark);outline-offset:2px}.focus-ring:focus-visible{border-radius:var(--radius-sm)}.below-fold-section{content-visibility:auto;contain-intrinsic-size:0 600px}@media (min-width:1024px){.chat-panel-open body{margin-right:420px}.chat-panel-open body,body{transition:margin-right .3s ease-out}}@property --tw-translate-x{syntax:"*";inherits:false;initial-value:0}@property --tw-translate-y{syntax:"*";inherits:false;initial-value:0}@property --tw-translate-z{syntax:"*";inherits:false;initial-value:0}@property --tw-scale-x{syntax:"*";inherits:false;initial-value:1}@property --tw-scale-y{syntax:"*";inherits:false;initial-value:1}@property --tw-scale-z{syntax:"*";inherits:false;initial-value:1}@property --tw-rotate-x{syntax:"*";inherits:false}@property --tw-rotate-y{syntax:"*";inherits:false}@property --tw-rotate-z{syntax:"*";inherits:false}@property --tw-skew-x{syntax:"*";inherits:false}@property --tw-skew-y{syntax:"*";inherits:false}@property --tw-space-y-reverse{syntax:"*";inherits:false;initial-value:0}@property --tw-divide-y-reverse{syntax:"*";inherits:false;initial-value:0}@property --tw-border-style{syntax:"*";inherits:false;initial-value:solid}@property --tw-gradient-position{syntax:"*";inherits:false}@property --tw-gradient-from{syntax:"";inherits:false;initial-value:#0000}@property --tw-gradient-via{syntax:"";inherits:false;initial-value:#0000}@property --tw-gradient-to{syntax:"";inherits:false;initial-value:#0000}@property --tw-gradient-stops{syntax:"*";inherits:false}@property --tw-gradient-via-stops{syntax:"*";inherits:false}@property --tw-gradient-from-position{syntax:"";inherits:false;initial-value:0}@property --tw-gradient-via-position{syntax:"";inherits:false;initial-value:50%}@property --tw-gradient-to-position{syntax:"";inherits:false;initial-value:100%}@property --tw-leading{syntax:"*";inherits:false}@property --tw-font-weight{syntax:"*";inherits:false}@property --tw-tracking{syntax:"*";inherits:false}@property --tw-ordinal{syntax:"*";inherits:false}@property --tw-slashed-zero{syntax:"*";inherits:false}@property --tw-numeric-figure{syntax:"*";inherits:false}@property --tw-numeric-spacing{syntax:"*";inherits:false}@property --tw-numeric-fraction{syntax:"*";inherits:false}@property --tw-shadow{syntax:"*";inherits:false;initial-value:0 0 #0000}@property --tw-shadow-color{syntax:"*";inherits:false}@property --tw-shadow-alpha{syntax:"";inherits:false;initial-value:100%}@property --tw-inset-shadow{syntax:"*";inherits:false;initial-value:0 0 #0000}@property --tw-inset-shadow-color{syntax:"*";inherits:false}@property --tw-inset-shadow-alpha{syntax:"";inherits:false;initial-value:100%}@property --tw-ring-color{syntax:"*";inherits:false}@property --tw-ring-shadow{syntax:"*";inherits:false;initial-value:0 0 #0000}@property --tw-inset-ring-color{syntax:"*";inherits:false}@property --tw-inset-ring-shadow{syntax:"*";inherits:false;initial-value:0 0 #0000}@property --tw-ring-inset{syntax:"*";inherits:false}@property --tw-ring-offset-width{syntax:"";inherits:false;initial-value:0}@property --tw-ring-offset-color{syntax:"*";inherits:false;initial-value:#fff}@property --tw-ring-offset-shadow{syntax:"*";inherits:false;initial-value:0 0 #0000}@property --tw-outline-style{syntax:"*";inherits:false;initial-value:solid}@property --tw-blur{syntax:"*";inherits:false}@property --tw-brightness{syntax:"*";inherits:false}@property --tw-contrast{syntax:"*";inherits:false}@property --tw-grayscale{syntax:"*";inherits:false}@property --tw-hue-rotate{syntax:"*";inherits:false}@property --tw-invert{syntax:"*";inherits:false}@property --tw-opacity{syntax:"*";inherits:false}@property --tw-saturate{syntax:"*";inherits:false}@property --tw-sepia{syntax:"*";inherits:false}@property --tw-drop-shadow{syntax:"*";inherits:false}@property --tw-drop-shadow-color{syntax:"*";inherits:false}@property --tw-drop-shadow-alpha{syntax:"";inherits:false;initial-value:100%}@property --tw-drop-shadow-size{syntax:"*";inherits:false}@property --tw-backdrop-blur{syntax:"*";inherits:false}@property --tw-backdrop-brightness{syntax:"*";inherits:false}@property --tw-backdrop-contrast{syntax:"*";inherits:false}@property --tw-backdrop-grayscale{syntax:"*";inherits:false}@property --tw-backdrop-hue-rotate{syntax:"*";inherits:false}@property --tw-backdrop-invert{syntax:"*";inherits:false}@property --tw-backdrop-opacity{syntax:"*";inherits:false}@property --tw-backdrop-saturate{syntax:"*";inherits:false}@property --tw-backdrop-sepia{syntax:"*";inherits:false}@property --tw-duration{syntax:"*";inherits:false}@property --tw-ease{syntax:"*";inherits:false}@keyframes spin{to{transform:rotate(1turn)}}@keyframes pulse{50%{opacity:.5}}@keyframes bounce{0%,to{animation-timing-function:cubic-bezier(.8,0,1,1);transform:translateY(-25%)}50%{animation-timing-function:cubic-bezier(0,0,.2,1);transform:none}}

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