In ophthalmology, ‘neuroprotection’ usually refers to methods of preventing progressive glaucomatous visual field loss that are not intraocular pressure (IOP) reduction treatments. The term also includes the possibility of recovery of optic nerve function in glaucoma. Nicotinamide is a form of vitamin B3, which is transformed into nicotinamide adenine dinucleotide (NAD) within mitochondria. NAD is a major chemical in all the vital processes of cellular metabolism and is also critical for DNA repair through the Sirtuin pathway.
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