SPONSORED: Systane COMPLETE PRESERVATIVE-FREE Lubricant Eye Drops launched in Australia and New Zealand

April 6, 2022 Sponsored feature

Alcon has once again expanded its range of preservative-free eye drops with the addition of Systane COMPLETE PRESERVATIVE-FREE Lubricant Eye Drops. This lubricating eye drop combines the long-lasting formulation of Systane COMPLETE with a multi-dose, preservative-free bottle.

 

Systane COMPLETE utilises Systane’s Intelligent Delivery system of HP-guar and borate in combination with nano-lipid technology to support all layers of the tear film and relieve the symptoms of all types of dry eye (Aqueous Deficient, Evaporative and Mixed Dry Eye)¹^,². Upon instillation, the HP-guar and borate crosslink to form a viscoelastic meshwork³. This meshwork forms a bandage over the ocular surface, preferentially binding to damaged areas of the cornea⁴ and increasing retention of the demulcents in the drop, for extended protection and lubrication²^,³. The nano-emulsion is formulated with mineral oil and a patented anionic phospholipid delivered in nano-sized lipid droplets⁵. The nano-size droplets provide three benefits: they optimise the lipid surface coverage², the emulsion formulation is less opaque² and allows an increase in HP-guar compared to Systane BALANCE Lubricant Eye Drops for increased retention³.

 

In Systane BALANCE Lubricant Eye Drops the highest concentration of HP-guar in the formulation before coalescence occurred was established at 0.05⁶. In Systane COMPLETE, HP-guar is three times the concentration at 0.15%⁶. This difference is due to the lipids in Systane COMPLETE being converted to the nanoemulsion⁶.

 

The multidose, preservative-free bottle features patented PureFlow Technology, which is comprised of a one-way valve to ensure no contaminated liquid can be re-introduced into the container and a fine silicone membrane to filter returned air⁷. The bottle has a low squeeze force and features a blue tip to aid targeting of the eye for ease of instillation⁷. This bottle was rated highly by patients for ease of use⁸. In a survey of 100 eye drop users, the preferred features mentioned included: it was easy to dispense a drop, it was easy hold and handle and the blue tip helped them to better target the eye⁸.

 

TFOS DEWS II states preservative-free drops may be a good choice for frequent users and users of multiple eye drops⁹. Dry eye sufferers may be using multiple types of drops, for example glaucoma medications or allergy eye drops together with ocular lubricants. In a survey of over 1,100 users of lubricating eye drops, 50.6% of those surveyed used drops between one and three times a day and 4.3% used them four or more times per day¹⁰.

 

Systane COMPLETE PRESERVATIVE-FREE is suitable for those with mild to moderate dry eye* in any of the sub-categories (ADDE, EDE or mixed)¹^,² and provides symptomatic relief of dry eye for up to eight hours².

 

*Recommendation based upon expected on-eye viscosity

 

References

1. Rangarajan, R and Ketelson, H. Preclinical Evaluation of a New Hydroxypropyl-Guar Phospholipid Nanoemulsion-Based Artificial Tear Formulation in Models of Corneal Epithelium. 1, s.l. : Mary Ann Liebert, Inc, 2019, Journal of Ocular Pharmacology and Therapeutics, Vol. 35.

2. Silverstein et al. Symptom Relief Following a Single Dose of Propylene Glycol-Hydroxypropyl Guar Nanoemulsion in Patients with Dry Eye Disease: A Phase IV, Multicenter Trial Clin Ophthalmol 2020; 14: 3167-3177. Sponsored by Alcon

3. Springs, C. Novel Ocular Lubricant Containing an Intelligent Delivery System: Details of Its Mechanism of Action. Dev Ophthalmol. Basel, Karger, 2010, vol 45, pp 139–147

4. Alison Ng, et al. Tear osmolarity changes after use of hydroxypropyl-guar-based lubricating eye drops. Clin Ophthalmol. 2018 Apr 10;12:695-700.

5. Ketelson H, Rangarjan R. Pre-clinical evaluation of a novel phospholipid nanoemulsion based lubricant eye drops. Poster presented at ARVO 2017, Baltimore, MD

6. Alcon data on file, 2017 Ref 01748 Page 9-11,23

7. Nemera Novelia Product Leaflet, 2015. Available: www.nemera.net/wp-content/uploads/2014/06/Brochure_Ophthalmic.pdf (Accessed 23-Jul-2021)

8. Seller, F. Nemera user Testing ((n=30; n=90; n=20): https://www.nemera.net/wp-content/uploads/2019/01/ Nemera_Ophthalmic_OnDrugDelivery.pdf

9. Jones, L., et al. TFOS DEWS II Management and Therapy Report. The Ocular Surface. 2017; pp. 580-634

10. Vision Needs Monitor 2020 (Ref11235). N= 1318 Dry Eye Sufferers, pp143-144

 

Always follow the directions for use. © 2022 Alcon Laboratories Pty Ltd. Australia: 1800 224 153. Auckland, New Zealand: 0800 101 106