Intraocular lymphoma (IOL) comprises a heterogenous group of malignant lymphocytic neoplasms arising from either within the central nervous system as a primary intraocular lymphoma (PIOL) – a subset of primary CNS lymphoma (PCNSL) – or outside the central nervous system (CNS) as a metastasis from a non-ocular neoplasm (secondary intraocular lymphoma)1. In PIOL the lymphoma cells are confined only to the eye, with no evidence of spread to the brain or cerebrospinal fluid (CSF), although concomitant and subsequent intracranial involvement is common2. Almost all cases of PIOL are reported to be B-cell type in origin and fall within the category of diffuse large B-cell lymphomas, with fewer cases being of T-cell origin3.
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