Researchers from King’s College London, University College London, Massachusetts Eye and Ear and Harvard Medical School have identified 133 genetic variants which could pave the way for glaucoma screening and early intervention.
The breakthrough represents a major advance in the fight to tackle the degenerative condition, which has virtually no symptoms in the early stages and affects millions worldwide.
Scientists studied 140,000 people drawn from the UK Biobank and EPIC-Norfolk. Eye pressure readings were compared with a DNA analysis of each patient to assess how likely it was that they would develop the condition. By comparing the pressure test results with a genetic analysis of the many common, small variations in DNA that contribute a tiny amount to overall eye pressure, the team was able to identify 133 genetic variants in the DNA of those who had high pressure readings, and so were at highest risk of developing the condition. The genetic variations were able to predict whether someone might develop glaucoma with 75% accuracy.
Lead author, Dr Pirro Hysi from King’s College London, said: ‘Knowing someone’s genetic risk profile might allow us to predict what risk of glaucoma he or she carries so that in the future we can focus scarce health care resources on those most at risk.’
Co-author Dr Anthony Khawaja from the NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, said: “The predictive genetic markers could be measured as early as birth, even though glaucoma develops later in adulthood. These results help us to better understand the previously unknown mechanisms that cause this damaging disease. By understanding how glaucoma develops we can, in time, get ahead of the curve of the condition and support both those living with the disease and those who may develop it.”
Dr. Janey Wiggs, co-author from Massachusetts Eye and Ear and Harvard Medical School said, “This study demonstrates the enormous power of large datasets allowing detection of these important genetic risk factors. “Glaucoma remains the leading cause of incurable blindness in the world, but the hope is that this important piece of research could help millions by leading to faster and more accurate diagnoses in the future.”
