Hot topics with Retina Specialists

Lucky escape

Impressed by the ophthalmic knowledge in the room, Dr Rachel Barnes quizzed optometrists on the potential diagnoses and investigative techniques for three cases involving ocular ischaemic syndrome, lupus and myelinated nerve fibres.

Referred by his optometrist, the ‘lucky escape’ was a 59-year-old male who presented with spotted retinal haemorrhages during a routine eye examination. Imaging revealed scattered block haemorrhages and engorged-looking veins in the right eye, while the left eye looked normal. He had slightly blurry vision in the right eye, normal anterior segment and no significant cataract. Having checked the venous pressure wasn’t raised, Dr Barnes said she listened to the carotids and could hear a bruit (a sort of turbulent flow synchronised with the heartbeat) on the left side, while the affected right side was pretty quiet. Suspecting ocular ischaemic syndrome, Dr Barnes ordered a carotid ultrasound.

The result was alarming: severe plaques in both common carotid arteries, severe plaques at the origin of both internal carotids, 80–99% stenosis of the right proximal internal carotid artery and 70–79% stenosis of the internal carotid artery and both external carotid arteries. “He was a walking time bomb,” Dr Barnes said, adding there was so little flow on the right, affected side you couldn't even hear the bruit.

The man was urgently referred to vascular surgeons and had an endarterectomy on his right side within days and the left one done about four weeks later. Seeing Dr Barnes some days after his second endarterectomy, the patient said he was feeling so much better and clearer in the head. “Turns out it's quite good to have blood going to your brain!” she said.

AI in practice

Dr Leo Sheck piqued optometrists’ interest with talk on the use of artificial intelligence (AI) in practice. Sharing a case of hydroxychloroquine retinal toxicity, he said a newly developed open-source AI tool called HCQquery can detect the presence of hydroxychloroquine retinopathy and predict its future occurrence from spectral-domain OCT (SD-OCT) images. Dr Sheck said the algorithm achieves excellent performance metrics, with an accuracy of 0.987, sensitivity of 1.00 and specificity of 0.983. He said it’s important to note these tools are unregulated, so they can only be used in a research setting.

“Ultimately, you need to make your own clinical decision. What I do is that I only use the algorithm at the end for verification, having formulated my diagnosis first,” Dr Sheck said. “Because, little by little, like seeing other people's choices on the screen when doing quizzes, it will influence what you choose. Seeing a result from a deep-learning algorithm will influence how I interpret the scan, so it’s really important that you do everything yourself first and then maybe run the algorithm on the imaging just to confirm what you concluded from the imaging.”

Hope on the horizon


Wen Li, Jacqueline Ling and Christina Herrick

Having recently returned from the American Society of Retina Specialists’ annual meeting, Dr Sheck said there was a lot of discussion on management of geographic atrophy and intermediate AMD. He said there is something good on the horizon for these patients, beyond the Amsler grid and supplements: photobiomodulation (PBM). LumiThera’s Valeda Light Delivery System was approved by the FDA late last year and Dr Sheck said he anticipates it will be available in New Zealand next year, now Alcon has acquired the company.

PBM is a non-invasive treatment using low-level light therapy in three distinct wavelengths of yellow, red and near-infrared radiation to stimulate mitochondrial energy production, promoting retinal cellular health. It’s administered to the patient while they sit comfortably in a chair, and they come in for nine sessions over three to five weeks, have a break for four months, then return and do it again. Trials have shown the treatment improves visual acuity; however, more interestingly, the macular drusen volume decreased following treatment, Dr Sheck said. “That's probably more convincing, people who have been treated have got less drusen. Still, a decrease in volume of drusen may not always be a good thing, as they sometimes collapse and leave behind atrophy. But what they've shown in this study is people who have been treated with photobiomodulation have less incidence of new-onset geographic atrophy as well, so that is looking quite encouraging.”

On that positive note, Retina Specialists wrapped up another successful education evening.

HCQuery is available here The algorithm will accept OCT images in png, tiff or jpg formats.